
Cell Disruption: Getting the RNA Out | Thermo Fisher ...
Mechanical. Cell and tissue disruption methods are usually mechanical or enzymatic. Mechanical methods for disrupting fresh tissue and cells include homogenization with a Dounce or with a mechanical homogenizer (such as the Brinkmann Polytron®), vortexing, soniion, French press, bead milling, and even grinding in a coffee grinder!